Frazole Forte Mechanism of Action

Pharmacokinetics: Omeprazole is rapidly absorbed, but to a variable extent, following oral administration. Absorption of omeprazole is acid-labile and various formulation have been developed in an attempt to improve bioavailability from the gastro-intestinal tract. Consequently, its pharmacokinetics may vary with different formulation of the drug. The absorption of omeprazole, as well as being formulation dependent, also appears to be dose-dependent, is increasing the dosage above 40mg has been reported to increase plasma concentrations in a non-linear fashion.
Bioavailability with omeprazole may be increased in elderly patients. In some ethnic groups such as Chinese, and in patients with impaired hepatic function, but is not markedly affected  in patients with renal impairment.
Following absorption, omeprazole is almost completely metabolized in the liver, primarily  by cytochrome  P450 isoform CYP2C19, and rapidly eliminated mostly in the urine. Although the elimination half-life from plasma is short being reported to be about 0.5 to 3.0 hours, its duration of action with regard to inhibition of acid secretion is much longer allowing it to be used in single daily doses. Omeprazole is highly bound (about 95%) to plasma proteins.